Diabetes mellitus
Diabetes mellitus is a disease closely linked to obesity. While type 1 diabetes is caused by a deficiency of insulin producing beta-cells due to autoimmunity and independent of obesity, the more prevalent type 2 diabetes is directly related to overweight in humans and rodents. Type 2 diabetes affects at least 6% of the population of westernized countries, while possibly up to half of the affected individuals are currently undiagnosed. Diabetes is the seventh leading cause of death according to the US CDC’s National Center for Health Statistics, and is the leading cause of kidney failure, blindness, and amputation in adults. As for obesity the prevalence of type 2 diabetes increases with age: While there is increasing prevalence of juvenile type 2 diabetes, more than 18% of individuals 65 years or older are suffering from diabetes. While obesity is not essential for the development of obesity, and obesity does not automatically leads to diabetes, there is no doubt about the fact the an increase in bodyweight dramatically increases the incidence of diabetes: dependent on the increase of bodyweight an up to 40-fold increased risk for type 2 diabetes is observed. Since type 2 diabetes is caused by a combination of insufficiency of the pancreatic beta-cell to secrete appropriate amounts of insulin and a decreased efficiency of insulin to promote glucose uptake and metabolism in peripheral tissues like skeletal muscle and white fat, to figure out the causative role of obesity on these pathogenetic sequelae is one of the main focuses of current diabetes research
Diabetes mellitus is a disease closely linked to obesity. While type 1 diabetes is caused by a deficiency of insulin producing beta-cells due to autoimmunity and independent of obesity, the more prevalent type 2 diabetes is directly related to overweight in humans and rodents. Type 2 diabetes affects at least 6% of the population of westernized countries, while possibly up to half of the affected individuals are currently undiagnosed. Diabetes is the seventh leading cause of death according to the US CDC’s National Center for Health Statistics, and is the leading cause of kidney failure, blindness, and amputation in adults. As for obesity the prevalence of type 2 diabetes increases with age: While there is increasing prevalence of juvenile type 2 diabetes, more than 18% of individuals 65 years or older are suffering from diabetes. While obesity is not essential for the development of obesity, and obesity does not automatically leads to diabetes, there is no doubt about the fact the an increase in bodyweight dramatically increases the incidence of diabetes: dependent on the increase of bodyweight an up to 40-fold increased risk for type 2 diabetes is observed. Since type 2 diabetes is caused by a combination of insufficiency of the pancreatic beta-cell to secrete appropriate amounts of insulin and a decreased efficiency of insulin to promote glucose uptake and metabolism in peripheral tissues like skeletal muscle and white fat, to figure out the causative role of obesity on these pathogenetic sequelae is one of the main focuses of current diabetes research
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